Orange 3.0 version comes with an exciting feature that will simplify reading your data. If the old Orange required conversion from Excel into either tab-delimited or comma-separated files, the new version allows you to open plain .xlsx format data sets in the program. Naturally, the .txt and .csv files are still readable in Orange, so feel free to use data sets in any of the above-mentioned formats.
Since Orange 3.0 is still in the development mode, you will find a smaller selection of widgets available at the moment, but give it a go and see how it works for Excel type data and whether the existing widgets are sufficient for your data analysis. Please find the daily build for OSX here.
Orange 3.0 can read Excel files.